Simultaneous determination of ribonucleoside and deoxyribonucleoside triphosphates in biological samples by hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry

Author:

Kong Ziqing1,Jia Shaodong1,Chabes Anna Lena1,Appelblad Patrik23,Lundmark Richard45,Moritz Thomas6,Chabes Andrei15

Affiliation:

1. Department of Medical Biochemistry and Biophysics, Umeå University, SE-901 87 Umeå, Sweden

2. Department of Pharmacology and Clinical Neuroscience, Umeå University, SE-901 87, Umeå, Sweden

3. Merck Chemicals and Life Science AB, SE 169-03 Solna, Sweden

4. Dept. of Integrative Medical Biology, Umeå University, SE-901 87 Umeå, Sweden

5. Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, SE-901 87 Umeå, Sweden

6. Umeå Plant Science Centre (UPSC), Dept. of Forest Genetics and Plant Physiology, SLU, SE-901 87 Umeå, Sweden

Funder

Swedish Research Council

Swedish Cancer Society

Publisher

Oxford University Press (OUP)

Subject

Genetics

Reference40 articles.

1. Interactions between deoxyribonucleotide and DNA synthesis;Reichard;Annu. Rev. Biochem.,1988

2. International Commission for Protection Against Environmental Mutagens and Carcinogens. Deoxyribonucleoside triphosphate levels: a critical factor in the maintenance of genetic stability;Kunz;Mutat. Res.,1994

3. Genome-wide analysis of the specificity and mechanisms of replication infidelity driven by imbalanced dNTP pools;Watt;Nucleic Acids Res.,2016

4. Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools;Kumar;Nucleic Acids Res.,2011

5. Survival of DNA damage in yeast directly depends on increased dNTP levels allowed by relaxed feedback inhibition of ribonucleotide reductase;Chabes;Cell,2003

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