Affiliation:
1. Unidad de Educación e Investigación, Instituto Mexicano del Seguro Social, Centro de Investigación Biomédica de Oriente , Km 4.5 Carretera Atlixco-Metepec, 74360 Puebla , Mexico
Abstract
Abstract
Leukemia stem cells are known to drive tumor progression, drug resistance, microenvironmental shift, and relapse, which would make them a perfect therapeutic target. However, their phenotypic and functional similarity to their normal counterparts leaves limited road maps for their selective elimination. Tremblay et al. recently unraveled the fundamental role of overactivated pSTAT5 as a functional marker of early T cell precursor acute lymphoblastic leukemia stem cells driving leukemic progression and highlighted its potential use as a therapeutic target to prevent fatal outcomes.
Funder
National Council of Science and Technology
Publisher
Oxford University Press (OUP)
Subject
Cell Biology,Immunology,Immunology and Allergy