The Fat Controller: an unexpected role of SELENOI in IgM responses

Author:

Bemark Mats12

Affiliation:

1. Department of Translational Medicine—Human Immunology, Lund University , J Waldenströms gata 35, Malmö 214 28 , Sweden

2. Department of Clinical Immunology and Transfusion Medicine, Sahlgrenska University Hospital , Region Västra Götaland, Gothenburg 413 46 , Sweden

Abstract

SELENOI-produced lipids play roles in peripheral B cell differentiation

Publisher

Oxford University Press (OUP)

Reference13 articles.

1. Metabolic adaptation of lymphocytes in immunity and disease;Chapman;Immunity,2022

2. Metabolic control of T(FH) cells and humoral immunity by phosphatidylethanolamine;Fu;Nature,2021

3. Biology and roles in diseases of selenoprotein I characterized by ethanolamine phosphotransferase activity and antioxidant potential;Li;J Nutr,2023

4. Selenoprotein I deficiency in T cells promotes differentiation into tolerant phenotypes while decreasing Th17 pathology;Ma;J Leukoc Biol,2022

5. Upregulated Selenoprotein I during LPS-induced B cell activation promotes lipidomic changes and is required for effective differentiation into IgM secreting plasma B cells.;Ma;J Leukoc Biol,2024

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