TIM-3 signaling contributes to the suppressive capacity of Tregs from people with HIV on antiretroviral therapy

Author:

Nieves-Rosado Hector M1ORCID,Jacobs Jana L2,Naqvi Asma2,Mellors John W2,Macatangay Bernard J C2,Kane Lawrence P3

Affiliation:

1. Program in Microbiology and Immunology, University of Pittsburgh School of Medicine , Pittsburgh, PA 15261 , United States

2. Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261 , United States

3. Department of Immunology, University of Pittsburgh School of Medicine , Pittsburgh, PA 15261 , United States

Abstract

Abstract TIM-3 expression is increased on peripheral regulatory T cells (Tregs) of virally suppressed persons with HIV-1 on antiretroviral therapy (PWH-ART). However, the relevance of TIM-3 expression in this setting is unclear. We used flow cytometry to evaluate the suppressive phenotype and signaling pathways in peripheral TIM-3− vs TIM-3+ Tregs in PWH-ART. TIM-3+ Tregs showed increased expression of IL-10 compared with persons without HIV-1. In addition, TIM-3+ Tregs displayed elevated signaling and activation, relative to TIM-3− Tregs from the same PWH-ART. Dramatically, TIM-3 blockade restrained the in vitro suppressive capacity of peripheral Tregs. Therefore, our data demonstrate not only that TIM-3 expression by Tregs is associated with an immunosuppressive response among PWH-ART, but also that TIM-3 contributes directly to the enhanced suppressive activity of Tregs in this setting.

Funder

Public Health Service

University of Pittsburgh School of Medicine

Publisher

Oxford University Press (OUP)

Subject

Cell Biology,Immunology,Immunology and Allergy

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