The mechanism of efferocytosis in the pathogenesis of periodontitis and its possible therapeutic strategies

Author:

Huang Zhanyu12,Zhao Qingtong13,Jiang Xinrong12,Li Zejian124

Affiliation:

1. Hospital of Stomatology, The First Affiliated Hospital of Jinan University, Jinan University , No. 613, West Huangpu Avenue, Tianhe District, Guangzhou City, Guangdong Province 510630 , China

2. College of Stomatology, Jinan University , No. 601, West Huangpu Avenue, Tianhe District, Guangzhou City, Guangdong Province 510632 , China

3. Department of Stomatology, The Sixth Affiliated Hospital of Jinan University , No. 88, Changdong Avenue, Changping Town, Dongguan City, Guangdong Province 523573 , China

4. Chaoshan Hospital, The First Affiliated Hospital of Jinan University , No. 161, Caichang Avenue, Raoping County, Chaozhou City, Guangdong Province 515600 , China

Abstract

AbstractPeriodontitis is an inflammatory disease characterized by the destruction of periodontal tissues, and its etiology is related to several systemic factors. At present, the destruction of periodontal tissues is considered to be the result of inflammation resolution disorders. Efferocytosis plays an important role in the resolution of inflammation, and defective efferocytosis is an essential factor in the persistence of many chronic inflammatory diseases. Therefore, this review will describe the mechanisms involved in the efferocytosis of macrophages in the pathogenesis of periodontitis and highlight emerging therapeutic strategies to provide new ideas for future periodontal treatment.

Publisher

Oxford University Press (OUP)

Subject

Cell Biology,Immunology,Immunology and Allergy

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