Gas Chromatographic Determination of Phenolic Compounds in Drug Preparations: Collaborative Study

Author:

Douglas Carol C1

Affiliation:

1. National Center for Drug Analysis, Food and Drug Administration, 1114 Market St., St. Louis, Mo. 63101

Abstract

Abstract A gas chromatographic method for the determination of phenol, methyl salicylate, menthol , and camphor in drug preparations was studied collaboratively by 9 laboratories. Mean recoveries were: phenol 98.2, 106.0, a n d 103.6%; methyl salicylate 103.9, 102.0, and 101.9%; menthol 102.9 and 100.9%; and camphor 101.9 and 100.9%. The method has been adopted as official first action for camphor-containing drugs. Additional study will be done to improve recoveries for the other 3 compounds.

Publisher

Oxford University Press (OUP)

Subject

General Chemistry

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