Efficacy and Safety of ATX-101 by Treatment Session: Pooled Analysis of Data From the Phase 3 REFINE Trials

Author:

Dayan Steven H1,Schlessinger Joel2,Beer Kenneth3,Donofrio Lisa M4,Jones Derek H5,Humphrey Shannon6,Carruthers Jean7,Lizzul Paul F8,Gross Todd M9,Beddingfield Frederick C10,Somogyi Christine11

Affiliation:

1. Department of Otolaryngology, University of Illinois and a plastic surgeon in private practice in Chicago, IL

2. Dermatologist in Private practice in Omaha, NE

3. Dermatologist in Private practice in West Palm Beach, FL

4. Department of Dermatology, Yale University School of Medicine, New Haven, CT

5. David Geffen School of Medicine, University of California Los Angeles and a dermatologist in private practice in Los Angeles, CA

6. Department of Dermatology and Skin Science, University of British Columbia and a dermatologist in private practice in Vancouver, British Columbia, Canada

7. Department of Ophthalmology and Visual Sciences, University of British Columbia and a dermatologist in private practice in Vancouver, British Columbia, Canada

8. Kythera Biopharmaceuticals, Inc. (an affiliate of Allergan), Westlake Village, CA

9. Clinical Development, Biostatistics and Data Management (at the time of this study), Kythera Biopharmaceuticals, Inc. (an affiliate of Allergan) and is an Associate Professor, Department of Statistics and Applied Probability, University of California Santa Barbara, Santa Barbara, CA

10. Kythera Biopharmaceuticals, Inc. (an affiliate of Allergan) and is an Assistant Clinical Professor of Medicine/Dermatology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA

11. Clinical Development (at the time of this study), Allergan plc, Irvine, CA

Funder

Kythera Biopharmaceuticals, Inc

Publisher

Oxford University Press (OUP)

Subject

General Medicine,Surgery

Reference7 articles.

1. Humphrey S , DayanSH, ShridharaniSM, BaumannL, GallagherCJ. Personal and social impacts of submental fat in the US population [abstract]. Presented at the Fall Clinical Dermatology Conference; October 20–23, 2016; Las Vegas, NV, USA.

2. ATX-101 for reduction of submental fat: A phase III randomized controlled trial;Humphrey;J Am Acad Dermatol,2016

3. REFINE-1, a multi center, randomized, double-blind, placebo-controlled, phase 3 trial with ATX-101, an injectable drug for submental fat reduction;Jones;Dermatol Surg,2016

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