Peripartum management of hypertension: a position paper of the ESC Council on Hypertension and the European Society of Hypertension

Author:

Cífková Renata12,Johnson Mark R3,Kahan Thomas4,Brguljan Jana5,Williams Bryan6,Coca Antonio7ORCID,Manolis Athanasios8,Thomopoulos Costas9,Borghi Claudio10,Tsioufis Costas11,Parati Gianfranco1213,Sudano Isabella14,McManus Richard J15,van den Born Bert-Jan H16,Regitz-Zagrosek Vera17ORCID,de Simone Giovanni18

Affiliation:

1. Center for Cardiovascular Prevention, Charles University in Prague, First Faculty of Medicine and Thomayer Hospital, Vídeňská 800, 140 59 Prague 4, Czech Republic

2. Department of Medicine II, Charles University in Prague, First Faculty of Medicine, Prague, Czech Republic

3. Institute of Reproductive and Developmental Biology, Imperial College School of Medicine, Chelsea and Westminster Hospital, London, UK

4. Division of Cardiovascular Medicine, Department of Clinical Sciences, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden

5. Division of Internal Medicine, Department of Hypertension, Medical Faculty, University Medical Centre Ljubljana, Ljubljana, Slovenia

6. UCL Institute of Cardiovascular Sciences, University College London, London, UK

7. Hypertension and Vascular Risk Unit, Department of Internal Medicine, Hospital Clinic, University of Barcelona, Barcelona, Spain

8. Department of Cardiology, Asklepeion General Hospital, Athens, Greece

9. Department of Cardiology, Helena Venizelou General & Maternal Hospital, Athens, Greece

10. Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy

11. First Cardiology Clinic, Medical School, National and Kapodistrian University of Athens, Hippokration Hospital, Athens, Greece

12. Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy

13. Cardiology Unit, Department of Cardiovascular, Neural and Metabolic Sciences, Istituto Auxologico Italiano, IRCCS, S.Luca Hospital, Milan, Italy

14. Department of Cardiology, University Heart Center Zurich, University Hospital and University of Zurich, Zurich, Switzerland

15. Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK

16. Departments of Internal and Vascular Medicine, Department of Public Health, Amsterdam University Medical Centre, Amsterdam, The Netherlands

17. Berlin Institute for Gender in Medicine and CCR, Charité University Medicine Berlin, and DZHK, Partner Site Berlin, Germany

18. Department of Advanced Biomedical Sciences, Hypertension Research Center, Federico II University, Naples, Italy

Abstract

Abstract Hypertensive disorders are the most common medical complications in the peripartum period associated with a substantial increase in morbidity and mortality. Hypertension in the peripartum period may be due to the continuation of pre-existing or gestational hypertension, de novo development of pre-eclampsia or it may be also induced by some drugs used for analgesia or suppression of postpartum haemorrhage. Women with severe hypertension and hypertensive emergencies are at high risk of life-threatening complications, therefore, despite the lack of evidence-based data, based on expert opinion, antihypertensive treatment is recommended. Labetalol intravenously and methyldopa orally are then the two most frequently used drugs. Short-acting oral nifedipine is suggested to be used only if other drugs or iv access are not available. Induction of labour is associated with improved maternal outcome and should be advised for women with gestational hypertension or mild pre-eclampsia at 37 weeks’ gestation. This position paper provides the first interdisciplinary approach to the management of hypertension in the peripartum period based on the best available evidence and expert consensus.

Publisher

Oxford University Press (OUP)

Subject

Pharmacology (medical),Cardiology and Cardiovascular Medicine

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