Obesity and outcomes after left ventricular assist device implantation: insights from the EUROMACS Registry

Abstract

Abstract OBJECTIVES The objective was to analyse associations between obesity and outcomes after left ventricular assist device (LVAD) implantation. METHODS A retrospective analysis of the EUROMACS Registry was performed. Adult patients undergoing primary implantation of a continuous-flow LVAD between 2006 and 2019 were included (Medtronic HeartWare® HVAD®, Abbott HeartMate II®, Abbott HeartMate 3™). Patients were classified into 4 different groups according to body mass index at the time of surgery (body mass index <20 kg/m2: n = 254; 20–24.9 kg/m2: n = 1281; 25–29.9 kg/m2: n = 1238; ≥ 30 kg/m2: n = 691). RESULTS The study cohort was comprised of 3464 patients. Multivariable Cox proportional cause-specific hazards regression analysis demonstrated that obesity (body mass index ≥30 kg/m2) was independently associated with significantly increased risk of mortality (body mass index ≥30 vs 20–24.9 kg/m2: hazard ratio 1.36, 95% confidence interval 1.18–1.57, overall P < 0.001). Moreover, obesity was associated with significantly increased risk of infection and driveline infection. The probability to undergo heart transplantation was significantly decreased in obese patients (body mass index ≥30 vs 20–24.9 kg/m2: hazard ratio 0.59, 95% confidence interval 0.48–0.74, overall P < 0.001). CONCLUSIONS Obesity at the time of LVAD implantation is associated with significantly higher mortality and increased risk of infection as well as driveline infection. The probability to undergo heart transplantation is significantly decreased. These aspects should be considered when devising a treatment strategy before surgery.