Four-dimensional flow analysis reveals mechanism and impact of turbulent flow in the dissected aorta

Abstract

Abstract   OBJECTIVES This study aimed to explore the flow dynamics factors affecting turbulence formation in the false lumen (FL) of aortic dissection using four-dimensional flow magnetic resonance imaging (4D flow MRI). This study also aimed to uncover risk factors affecting late complications of aortic dissection. METHODS Thirty-three aortic dissection patients were examined using 4D flow MRI for quantitative flow dynamics (gross flow, velocity and regurgitant fraction) and turbulence visualization (helix and vortex with three-point visual grading) in the FL. The incidence of late complications (rupture or prophylactic intervention) was also obtained prospectively. RESULTS The helix grade was correlated with FL gross flow (rS = 0.55, P < 0.001) and FL velocity (rS = 0.45, P = 0.008). The vortex grade was also correlated with FL gross flow (rS = 0.70, P < 0.001) and FL velocity (rS = 0.67, P < 0.001). Comparative analysis of patients with complications and stable patients revealed that patients with complications exhibited higher FL gross flow [41.7 (interquartile range, IQR 29.1–59.7) vs 17.7 (IQR 9.0–42.0) ml/s; P = 0.01], higher helix grade [2 (IQR 1.25–2) vs 0 (IQR 0–1); P = 0.001] and higher vortex grade [2 (IQR 1–2) vs 0 (IQR 0–2); P = 0.01]. CONCLUSIONS Using 4D flow MRI analysis, we showed that turbulence formation depends on flow volume and velocity in the FL. Patients with high-volume turbulent flow in their FL are at higher risk of late complications; therefore, close follow-up and aggressive prophylactic intervention may improve their survival. Clinical trial registration number Nippon Medical School Hospital Institutional Review Board approved this observational study in September 2018 (No. 30-08-986).