Affiliation:
1. Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Clinical Pathology Unit , Milan , Italy
Abstract
Abstract
Background
In laboratory medicine, data collected in different settings or under different conditions are frequently analyzed to obtain meaningful information. Evaluation based only on location or variability measures, although useful, is not enough to extract all the value from data. Other mathematical or statistical approaches are possible, but the specific knowledge required is frequently out of the reach of most laboratorians. Computer simulation may help in solving the problem. The aim of this work was to use computer simulation for calculating reference limits for the overlap of 2 distributions.
Methods
Computer simulation was applied to find a reference value, and its confidence limits, from the overlapping area of 2 distributions when population means were allowed to differ by a pre-set amount. The allowable limits were compared with the overlapping area observed between data distributions reported from 3 laboratories. The simulation was run in R language. A description for the experimental setting was added, with the instructions for the simulation reported in structured English.
Results
The simulation allowed estimation of a limit to be used as a reference value when comparing two overlapping areas. Based on these limits, one laboratory in the study was found not to be aligned with the others.
Conclusions
Computer simulation is a low-cost, powerful, and easy to implement tool which may help in solving simple or complex problems, when assumptions are unrealistic or unmet, or when mathematical algorithms are not known or difficult to calculate.
Publisher
Oxford University Press (OUP)
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献