Do lead (Pb) content of lipsticks expose a health risk to children? A risk assessment study

Author:

Öztaş Demir Mesut123ORCID,Ulutaş Onur Kenan45ORCID,Berkkan Aysel12

Affiliation:

1. Faculty of Pharmacy , Department of Analytical Chemistry, , Ankara 06560 , Turkey

2. Gazi University , Department of Analytical Chemistry, , Ankara 06560 , Turkey

3. Turkey Drug and Medical Devices Agency , Ankara 06520 , Turkey

4. Faculty of Pharmacy , Department of Toxicology, , Ankara 06560 , Turkey

5. Gazi University , Department of Toxicology, , Ankara 06560 , Turkey

Abstract

Abstract Background Lead (Pb) content in lipsticks and potential life-long exposure of which might cause severe effects in consumers are an important concern for public. Thus, studies emphasize that lead exposure has no safe levels. Methods From 10 different brands, in total, 25 solid, gloss and creamy lipsticks are deployed from Turkish markets that are also categorized in two different price ranges. In order to evaluate the blood Pb levels in children, the United States Environmental Protection Agency’s ‘Exposure Uptake Biokinetic Model’ is utilized. To assess the health risk of chronic usage both for children and adults, oral daily systemic exposure levels are calculated with the worst-case scenario and are compared with Maximum Allowable Dose Level for lipsticks. For lifetime risk assessment, exposure is assumed to start by age 7, and four different exposure scenarios have been deployed. Results The mean lead content of lipsticks shows significant statistical differences between the high- and low-priced lipstick groups. Daily level and total risk for lifetime Pb exposure from deployed lipsticks are below the acceptable risk levels but long-worn usage of products with routine monitoring of metal content is crucial for sensitive and unintended exposure groups.

Publisher

Oxford University Press (OUP)

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