1. Health Education England Wessex , Winchester SO21 2RU , UK
2. MRC Lifecourse Epidemiology Centre , Southampton General Hospital, , Southampton SO16 6YD , UK
3. University of Southampton , Southampton General Hospital, , Southampton SO16 6YD , UK
4. NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust , Southampton SO16 6YD , UK
5. NIHR Applied Research Collaboration Wessex , Southampton Science Park, Innovation Centre, 2 Venture Road, Chilworth, Southampton SO16 7NP , UK