1. National Institute for Health Research Applied Research Collaboration West (NIHR ARC West), University Hospitals Bristol and Weston NHS Foundation Trust , Bristol BS1 2NT , UK
2. Centre for Academic Primary Care, University of Bristol , Bristol BS8 2PS , UK
3. Centre for Exercise, Nutrition & Health Sciences University of Bristol , Bristol BS8 1TZ , UK
4. Population Health Sciences , Bristol Medical School, , Bristol BS8 2PS , UK
5. University of Bristol , Bristol Medical School, , Bristol BS8 2PS , UK
6. Department of Health and Social Care, Office for Health Improvement and Disparities , 39 Victoria Street, London SW1H 0EU , UK