High resolution time-course mapping of early transcriptomic, molecular and cellular phenotypes in Huntington’s disease CAG knock-in mice across multiple genetic backgrounds-Reference-Cited by-同舟云学术

High resolution time-course mapping of early transcriptomic, molecular and cellular phenotypes in Huntington’s disease CAG knock-in mice across multiple genetic backgrounds

Published:2017-02-27 Issue:5 Volume:26 Page:913-922
ISSN:0964-6906
Container-title:Human Molecular Genetics
language:en
Short-container-title:

Author:

Ament Seth A.¹²,Pearl Jocelynn R.¹³,Grindeland Andrea⁴,St. Claire Jason⁵,Earls John C.¹⁶,Kovalenko Marina⁵,Gillis Tammy⁵,Mysore Jayalakshmi⁵,Gusella James F.⁵,Lee Jong-Min⁵,Kwak Seung⁷,Howland David⁷,Lee Min Young¹,Baxter David¹,Scherler Kelsey¹,Wang Kai¹,Geman Donald⁸,Carroll Jeffrey B.⁹,MacDonald Marcy E.⁵,Carlson George⁴,Wheeler Vanessa C.⁵,Price Nathan D.¹,Hood Leroy E.¹

Affiliation:

1. Institute for Systems Biology, Seattle, WA, USA

2. Institute for Genome Sciences and Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA

3. Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA, USA

4. McLaughlin Research Institute, Great Falls, MT, USA

5. Center for Human Genetic Research, Massachusetts General Hospital, Department of Neurology, Harvard Medical School, Boston, MA, USA

6. Department of Computer Science, University of Washington, Seattle, WA, USA

7. CHDI Management/CHDI Foundation, Princeton, NJ, USA

8. Department of Applied Mathematics and Statistics, Johns Hopkins University, Baltimore, MD, USA

9. Behavioral Neuroscience Program, Department of Psychology, Western Washington University, Bellingham, WA, USA

Funder

NIH

National Science Foundation

Publisher

Oxford University Press (OUP)

Subject

Genetics(clinical),Genetics,Molecular Biology,General Medicine

Link

http://academic.oup.com/hmg/article-pdf/26/5/913/25421047/ddx006.pdf

Reference47 articles.

1. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington’s disease chromosomes;The Huntington's Disease Collaborative Research Group;Cell,1993

2. Trinucleotide repeat length instability and age of onset in Huntington’s disease;Duyao;Nat. Genet,1993

3. The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington’s disease;Andrew;Nat. Genet,1993

4. A new model for prediction of the age of onset and penetrance for Huntington’s disease based on CAG length;Langbehn;Clin. Genet,2004

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