Safety and Immunogenicity of Newborn MVA85A Vaccination and Selective, Delayed Bacille Calmette-Guerin for Infants of Human Immunodeficiency Virus-Infected Mothers: A Phase 2 Randomized, Controlled Trial

Author:

Nemes Elisa1,Hesseling Anneke C2,Tameris Michele1,Mauff Katya1,Downing Katrina1,Mulenga Humphrey1,Rose Penelope2,van der Zalm Marieke2,Mbaba Sharon2,Van As Danelle1,Hanekom Willem A1,Walzl Gerhard3,Scriba Thomas J1,McShane Helen4,Hatherill Mark1,Abrahams Charmaine,Abrahams Deborah,Africa Hadn,Baartman Veronica,Bavuma Beauty,Bilek Nicole,Botes Natasja,Brown Yolande,Cloete Yolundi,Damons Margareth,De Vos Ronel,Dlakavu Portia,Du Preez Karen,Erasmus Mzwandile,Francis Claudia,Geldenhuys Hendrik,Geldenhuys Mandy,Goedeman Katriena,Golliath Sandra,Mouton Angelique Hendricks,Hopley Christiaan,Jansen Ruwijda,Jones Carolynne,Keyser Alana,Kagina Benjamin,Khomba Gloria,Kola–Cassiem Fazlin,Kruger Sandra,Leukes Daphne,Louw Loyiso,Luabeya Angelique,Maart Theresa,Makhethe Lebohang,Mbabwe Simbarashe,Mtshamba Eunice,Mvinjelwa Boniswa,Nkantsu Lungisa,Noble Julia,Nqweniso Sizwe,Opperman Fajwa,Petersen Christel,Plaatjie Patiswa,Rossouw Susan,Solomoms Roxanne,Steyn Marcia,Swanepoel Liticia,Toefy Asma,van Deventer Heidi,van Rooyen Elma,van Ster Daphne,Vazana Bongiwe,Veldsman Ashley,Xoyana Noncedo,

Affiliation:

1. South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease & Molecular Medicine and Division of Immunology, Department of Science & Technology/National Research Foundation, University of Cape Town

2. Desmond Tutu Tuberculosis Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences

3. DST/NRF Centre of Excellence for Biomedical Tuberculosis Research/Medical Research Council Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa

4. Jenner Institute, Oxford University, United Kingdom

Funder

Wellcome Trust

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Reference40 articles.

1. The BCG world atlas: a database of global BCG vaccination policies and practices;Zwerling;PLoS Med,2011

2. The clinical epidemiology of childhood pulmonary tuberculosis: a critical review of literature from the pre-chemotherapy era;Marais;Int J Tuberc Lung Dis,2004

3. The natural history of childhood intra-thoracic tuberculosis: a critical review of literature from the pre-chemotherapy era;Marais;Int J Tuberc Lung Dis,2004

4. The efficacy of bacillus Calmette-Guérin vaccination of newborns and infants in the prevention of tuberculosis: meta-analyses of the published literature;Colditz;Pediatrics,1995

5. Protection by BCG vaccine against tuberculosis: a systematic review of randomized controlled trials;Mangtani;Clin Infect Dis,2014

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