Immune Reconstitution Inflammatory Syndrome as a Posttransplantation Complication in Primary Immunodeficiency With Disseminated Mycobacterium avium-Reference-Cited by-同舟云学术

Immune Reconstitution Inflammatory Syndrome as a Posttransplantation Complication in Primary Immunodeficiency With Disseminated Mycobacterium avium

Published:2019-06-12 Issue:4 Volume:70 Page:676-679
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Manion Maura¹,Dimitrova Dimana²^ORCID,Pei Luxin¹,Gea-Banacloche Juan³,Zelazny Adrian⁴,Lisco Andrea¹,Zerbe Christa¹,Freeman Alexandra F¹,Holland Steven M¹,Kanakry Christopher G²,Kanakry Jennifer A²,Sereti Irini¹

Affiliation:

1. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland

2. National Cancer Institute, National Institutes of Health, Bethesda, Maryland

3. Mayo Clinic, Phoenix, Arizona

4. Department of Laboratory Medicine, National Institutes of Health, Bethesda, Maryland

Abstract

Abstract Patients with primary immunodeficiencies undergoing allogeneic hematopoietic cell transplantation (HCT) for difficult-to-control infections can experience immune reconstitution inflammatory syndrome (IRIS) following engraftment. In 3 patients with post-HCT IRIS related to mycobacterial infection, in vitro data demonstrate the emergence of pathogen-specific immune responses and a concomitant rise in plasma inflammatory markers.

Funder

National Institute of Allergy and Infectious Diseases

National Cancer Institute

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

http://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciz507/29107869/ciz507.pdf

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