Body mass index is negatively associated with telomere length: a collaborative cross-sectional meta-analysis of 87 observational studies-Reference-Cited by-同舟云学术

Body mass index is negatively associated with telomere length: a collaborative cross-sectional meta-analysis of 87 observational studies

Published:2018-09-01 Issue:3 Volume:108 Page:453-475
ISSN:0002-9165
Container-title:The American Journal of Clinical Nutrition
language:en
Short-container-title:

Author:

Gielen Marij¹^ORCID,Hageman Geja J²,Antoniou Evangelia E³,Nordfjall Katarina⁴,Mangino Massimo⁵⁶,Balasubramanyam Muthuswamy⁷,de Meyer Tim⁸,Hendricks Audrey E⁹¹⁰,Giltay Erik J¹¹,Hunt Steven C¹²,Nettleton Jennifer A¹³,Salpea Klelia D¹⁴,Diaz Vanessa A¹⁵,Farzaneh-Far Ramin¹⁶,Atzmon Gil¹⁷,Harris Sarah E¹⁸,Hou Lifang¹⁹,Gilley David²⁰,Hovatta Iiris²¹²²,Kark Jeremy D²³,Nassar Hisham²⁴,Kurz David J²⁵,Mather Karen A²⁶,Willeit Peter²⁷,Zheng Yun-Ling²⁸,Pavanello Sofia²⁹,Demerath Ellen W³⁰,Rode Line³¹,Bunout Daniel³²,Steptoe Andrew³³,Boardman Lisa³⁴,Marti Amelia³⁵³⁶³⁷,Needham Belinda³⁸,Zheng Wei³⁹,Ramsey-Goldman Rosalind⁴⁰,Pellatt Andrew J⁴¹,Kaprio Jaakko⁴²⁴³,Hofmann Jonathan N⁴⁴,Gieger Christian⁴⁵,Paolisso Giuseppe⁴⁶,Hjelmborg Jacob B H⁴⁷,Mirabello Lisa⁴⁶,Seeman Teresa⁴⁸,Wong Jason⁴⁹,van der Harst Pim⁵⁰,Broer Linda⁵¹,Kronenberg Florian⁵²,Kollerits Barbara⁵²,Strandberg Timo⁵³,Eisenberg Dan T A⁵⁴,Duggan Catherine⁵⁵,Verhoeven Josine E⁵⁶,Schaakxs Roxanne⁵⁶,Zannolli Raffaela⁵⁷,dos Reis Rosana M R⁵⁸,Charchar Fadi J⁵⁹,Tomaszewski Maciej⁶⁰⁶¹,Mons Ute⁶²⁶³,Demuth Ilja⁶⁴,Molli Andrea Elena Iglesias⁶⁵,Cheng Guo⁶⁶,Krasnienkov Dmytro⁶⁷,D'Antono Bianca⁶⁸,Kasielski Marek⁶⁹,McDonnell Barry J⁷⁰,Ebstein Richard Paul⁷¹,Sundquist Kristina⁷²,Pare Guillaume⁷³,Chong Michael⁷³,Zeegers Maurice P¹⁷⁴,

Affiliation:

1. Departments of Complex Genetics

2. Toxicology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht University, Netherlands

3. Department of Clinical Psychological Science, Faculty of Psychology and Neuroscience, Maastricht University, Netherlands

4. Department of Medicine, Östersund Hospital, Östersund, Sweden

5. Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

6. NIHR Biomedical Research Center at Guy's and St. Thomas’ Foundation Trust, London, United Kingdom

7. Cell and Molecular Biology, Madras Diabetes Research Foundation, Gopalapuram, Chennai, India

8. Department of Mathematical Modeling, Statistics, and Bioinformatics, Ghent University, Ghent, Belgium

9. Population Sciences Branch of the National Heart, Lung, and Blood Institute (NHLBI), NIH, NHLBI's Framingham Heart Study, Framingham, MA

10. Department of Mathematical and Statistical Sciences, University of Colorado–Denver, Denver, CO

11. Department of Psychiatry, Leiden University Medical Center, Leiden, Netherlands

12. Cardiovascular Genetics Division, Department of Medicine, University of Utah, Salt Lake City, UT

13. Division of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Science Center, Houston, TX

14. Department of Molecular Biology and Genetics, BSRC “Alexander Fleming,” Athens, Greece

15. Department of Family Medicine, Medical University of South Carolina, Charleston, SC

16. Division of Cardiology, San Francisco General Hospital, San Francisco, CA

17. Department of Medicine and Genetics, Albert Einstein College of Medicine, Bronx, NY, and Department of Biology, Faculty of Natural Science, University of Haifa, Haifa, Israel

18. Center for Cognitive Aging and Cognitive Epidemiology and Medical Genetics Section and Center for Genomics and Experimental Medicine and MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

19. Department of Preventive Medicine and Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL

20. Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN

21. Department of Biosciences, University of Helsinki, Helsinki, Finland

22. Department of Health, National Institute for Health and Welfare, Helsinki, Finland

23. Epidemiology Unit, Hebrew University–Hadassah School of Public Health and Community Medicine, Jerusalem, Israel

24. Department of Cardiology, Hadassah University Medical Center, Jerusalem, Israel

25. Department of Cardiology, Triemli Hospital, Zurich, Switzerland

26. Centre for Healthy Brain Ageing, Psychiatry, UNSW Australia, Sydney, Australia

27. Department of Neurology, Medical University Innsbruck, Innsbruck, Austria, and Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

28. Department of Oncology, Georgetown University Medical Center, Georgetown University, Washington, DC

29. Department of Cardiac, Thoracic, and Vascular Sciences, Unit of Occupational Medicine, University of Padova, Padova, Italy

30. Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN

31. The Copenhagen General Population Study, Department of Clinical Biochemistry, Copenhagen University Hospital, Herlev and Gentofte Hospital, Copenhagen, Denmark

32. Institute of Nutrition and Food Technology University of Chile, Santiago, Chile

33. Department of Epidemiology and Public Health, University College London, London, United Kingdom

34. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN

35. Department of Nutrition, Food Science, and Physiology, University of Navarra, Pamplona, Spain

36. Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain

37. CIBER Fisiopatología de la Obesidad y Nutrición, (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain

38. Department of Epidemiology, University of Michigan, Ann Arbor, MI

39. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN

40. Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL

41. Department of Medicine, University of Utah, Salt Lake City, UT

42. Department of Public Health

43. Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland

44. Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD

45. Research Unit of Molecular Epidemiology and Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

46. Department of Medical, Surgical, Neurological, Metabolic, and Geriatric Sciences, Second University of Naples, Naples, Italy

47. Department of Epidemiology, Biostatistics, and Biodemography, Institute of Public Health, University of Southern Denmark, Odense C, Denmark

48. Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA

49. Stanford University School of Medicine, Stanford, CA

50. Department of Cardiology, University Medical Center Groningen, Groningen, Netherlands

51. Department of Internal Medicine, Erasmus MC, Rotterdam, Netherlands

52. Division of Genetic Epidemiology, Department of Medical Genetics, Molecular, and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria

53. University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland; Center for Life Course Epidemiology, University of Oulu, Oulu, Finland

54. Department of Anthropology and Center for Studies in Demography and Ecology, University of Washington, Seattle, WA

55. The Fred Hutchinson Cancer Research Center, Seattle, WA

56. Department of Psychiatry, VU University Medical Center, Amsterdam Public Health Research Institute, Amsterdam, Netherlands

57. Pediatrics Unit, Azienda Ospedaliera Universitaria, Senese/University of Siena, Policlinico Le Scotte, Siena, Italy

58. Department of Gynecology and Obstetrics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil

59. School of Science and Technology, Federation University Australia, Department of Physiology, University of Melbourne, Melbourne, Australia, and Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom

60. Division of Cardiovascular Sciences, Faculty of Medicine, Biology, and Health, University of Manchester, Manchester, United Kingdom

61. Division of Medicine, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom

62. Division of Clinical Epidemiology and Aging Research

63. Cancer Prevention Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany

64. Charité–Universitätsmedizin Berlin (corporate member of Freie Universität Berlin), Humboldt-Universität zu Berlin, and Berlin Institute of Health, Lipid Clinic at the Interdisciplinary Metabolism Center, Berlin, Germany

65. CONICET-Universidad de Buenos Aires. Instituto de Inmunología, Genética y Metabolismo (INIGEM). Laboratorio de Diabetes y Metabolismo, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina

66. Department of Nutrition, Food Safety, and Toxicology, West China School of Public Health, Sichuan University, Chengdu, China

67. Department of Epigenetics, DF Chebotarev State Institute of Gerontology NAMS of Ukraine, Kyiv, Ukraine

68. Research Center, Montreal Heart Institute, and Psychology Department, University of Montreal, Montreal, Quebec, Canada

69. Bases of Clinical Medicine Teaching Center, Medical University of Lodz, Lodz, Poland

70. Cardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, United Kingdom

71. Department of Psychology, National University of Singapore, Singapore

72. Center for Primary Health Care Research, Lund University, Region Skåne, Lund, Sweden

73. Population Health Research Institute and McMaster University, Hamilton, Canada

74. CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, Netherlands

Abstract

ABSTRACT Background Even before the onset of age-related diseases, obesity might be a contributing factor to the cumulative burden of oxidative stress and chronic inflammation throughout the life course. Obesity may therefore contribute to accelerated shortening of telomeres. Consequently, obese persons are more likely to have shorter telomeres, but the association between body mass index (BMI) and leukocyte telomere length (TL) might differ across the life span and between ethnicities and sexes. Objective A collaborative cross-sectional meta-analysis of observational studies was conducted to investigate the associations between BMI and TL across the life span. Design Eighty-seven distinct study samples were included in the meta-analysis capturing data from 146,114 individuals. Study-specific age- and sex-adjusted regression coefficients were combined by using a random-effects model in which absolute [base pairs (bp)] and relative telomere to single-copy gene ratio (T/S ratio) TLs were regressed against BMI. Stratified analysis was performed by 3 age categories (“young”: 18–60 y; “middle”: 61–75 y; and “old”: >75 y), sex, and ethnicity. Results Each unit increase in BMI corresponded to a −3.99 bp (95% CI: −5.17, −2.81 bp) difference in TL in the total pooled sample; among young adults, each unit increase in BMI corresponded to a −7.67 bp (95% CI: −10.03, −5.31 bp) difference. Each unit increase in BMI corresponded to a −1.58 × 10−3 unit T/S ratio (0.16% decrease; 95% CI: −2.14 × 10−3, −1.01 × 10−3) difference in age- and sex-adjusted relative TL in the total pooled sample; among young adults, each unit increase in BMI corresponded to a −2.58 × 10−3 unit T/S ratio (0.26% decrease; 95% CI: −3.92 × 10−3, −1.25 × 10−3). The associations were predominantly for the white pooled population. No sex differences were observed. Conclusions A higher BMI is associated with shorter telomeres, especially in younger individuals. The presently observed difference is not negligible. Meta-analyses of longitudinal studies evaluating change in body weight alongside change in TL are warranted.

Publisher

Oxford University Press (OUP)

Subject

Nutrition and Dietetics,Medicine (miscellaneous)

Link

http://academic.oup.com/ajcn/article-pdf/108/3/453/28886513/nqy107.pdf

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