Smoking, Alcohol, and Biliary Tract Cancer Risk: A Pooling Project of 26 Prospective Studies
Author:
McGee Emma EORCID, Jackson Sarah SORCID, Petrick Jessica LORCID, Van Dyke Alison L, Adami Hans-Olov, Albanes DemetriusORCID, Andreotti Gabriella, Beane-Freeman Laura E, Berrington de Gonzalez Amy, Buring Julie E, Chan Andrew T, Chen Yu, Fraser Gary E, Freedman Neal D, Gao Yu-Tang, Gapstur Susan M, Gaziano J Michael, Giles Graham GORCID, Grant Eric J, Grodstein Francine, Hartge Patricia, Jenab Mazda, Kitahara Cari M, Knutsen Synnove F, Koh Woon-Puay, Larsson Susanna C, Lee I-Min, Liao Linda M, Luo JuhuaORCID, Milne Roger L, Monroe Kristine R, Neuhouser Marian L, O’Brien Katie M, Peters Ulrike, Poynter Jenny N, Purdue Mark P, Robien KimORCID, Sandler Dale PORCID, Sawada Norie, Schairer Catherine, Sesso Howard D, Simon Tracey G, Sinha Rashmi, Stolzenberg-Solomon Rachael, Tsugane ShoichiroORCID, Wang Renwei, Weiderpass Elisabete, Weinstein Stephanie JORCID, White Emily, Wolk Alicja, Yuan Jian-MinORCID, Zeleniuch-Jacquotte Anne, Zhang Xuehong, Zhu Bin, McGlynn Katherine A, Campbell Peter T, Koshiol JillORCID
Abstract
Abstract
Background
Tobacco and alcohol are well-established risk factors for numerous cancers, yet their relationship to biliary tract cancers remains unclear.
Methods
We pooled data from 26 prospective studies to evaluate associations of cigarette smoking and alcohol consumption with biliary tract cancer risk. Study-specific hazard ratios (HRs) and 95% confidence intervals (CIs) for associations with smoking and alcohol consumption were calculated. Random-effects meta-analysis produced summary estimates. All statistical tests were two-sided.
Results
Over a period of 38 369 156 person-years of follow-up, 1391 gallbladder, 758 intrahepatic bile duct, 1208 extrahepatic bile duct, and 623 ampulla of Vater cancer cases were identified. Ever, former, and current smoking were associated with increased extrahepatic bile duct and ampulla of Vater cancers risk (eg, current vs never smokers HR = 1.69, 95% CI = 1.34 to 2.13 and 2.22, 95% CI = 1.69 to 2.92, respectively), with dose-response effects for smoking pack-years, duration, and intensity (all Ptrend < .01). Current smoking and smoking intensity were also associated with intrahepatic bile duct cancer (eg, >40 cigarettes per day vs never smokers HR = 2.15, 95 % CI = 1.15 to 4.00; Ptrend = .001). No convincing association was observed between smoking and gallbladder cancer. Alcohol consumption was only associated with intrahepatic bile duct cancer, with increased risk for individuals consuming five or more vs zero drinks per day (HR = 2.35, 95%CI = 1.46 to 3.78; Ptrend = .04). There was evidence of statistical heterogeneity among several cancer sites, particularly between gallbladder cancer and the other biliary tract cancers.
Conclusions
Smoking appears to increase the risk of developing all biliary tract cancers except gallbladder cancer. Alcohol may increase the risk of intrahepatic bile duct cancer. Findings highlight etiologic heterogeneity across the biliary tract.
Funder
Intramural Program of the National Institutes of Health National Cancer Institute National Institute of Environmental Health Sciences National Institutes of Health Swedish Cancer Foundation
Publisher
Oxford University Press (OUP)
Subject
Cancer Research,Oncology
Cited by
74 articles.
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