1. Centre for Clinical Sciences, Hull York Medical School, University of Hull , Cottingham Road, Kingston-Upon-Hull, East Riding of Yorkshire HU6 7RX , UK
2. Department of Cardiology, Hull University Teaching Hospitals NHS Trust, Daisy Building, Castle Hill Hospital , Castle Road, Cottingham, Kingston-Upon-Hull, East Riding of Yorkshire HU16 5JQ , UK
3. School of Cardiovascular and Metabolic Health, British Heart Foundation Centre of Research Excellence , 126 University Place, University of Glasgow, Glasgow, Lanarkshire G12 8TA , UK