Micronutrient status in children aged 6–59 months with severe wasting and/or nutritional edema: implications for nutritional rehabilitation formulations

Author:

Vresk Laura1,Flanagan Mary1ORCID,Daniel Allison I12,Potani Isabel1ORCID,Bourdon Celine1ORCID,Spiegel-Feld Carolyn1,Thind Mehakpreet K1,Farooqui Amber1,Ling Catriona1,Miraglia Emiliano1,Hu Guanlan1,Wen Bijun1,Zlotkin Stanley2ORCID,James Philip3,McGrath Marie3,Bandsma Robert H J12

Affiliation:

1. Translational Medicine, The Hospital for Sick Children , Toronto, Ontario, Canada

2. Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto , Toronto, Ontario, Canada

3. Emergency Nutrition Network , Oxford, United Kingdom

Abstract

Abstract Undernutrition remains a global struggle and is associated with almost 45% of deaths in children younger than 5 years. Despite advances in management of severe wasting (though less so for nutritional edema), full and sustained recovery remains elusive. Children with severe wasting and/or nutritional edema (also commonly referred to as severe acute malnutrition and part of the umbrella term “severe malnutrition”) continue to have a high mortality rate. This suggests a likely multifactorial etiology that may include micronutrient deficiency. Micronutrients are currently provided in therapeutic foods at levels based on expert opinion, with few supportive studies of high quality having been conducted. This narrative review looks at the knowledge base on micronutrient deficiencies in children aged 6–59 months who have severe wasting and/or nutritional edema, in addition to highlighting areas where further research is warranted (See “Future Directions” section).

Publisher

Oxford University Press (OUP)

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