DNA damage response induces structural alterations in histone H3

DNA damage response induces structural alterations in histone H3–H4

Published:2017-01-01 Issue:1 Volume:58 Page:59-65
ISSN:0449-3060
Container-title:Journal of Radiation Research
language:en
Short-container-title:

Author:

Izumi Yudai¹,Fujii Kentaro²,Yamamoto Satoshi³,Matsuo Koichi¹,Namatame Hirofumi¹,Taniguchi Masaki¹,Yokoya Akinari²³

Affiliation:

1. Hiroshima Synchrotron Radiation Center, Hiroshima University, 2-313 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-0046, Japan

2. National Institutes for Quantum and Radiological Science and Technology (QST) 2-4, Ooaza-Shirakata, Tokai, Naka, Ibaraki 319-1106, Japan

3. Graduate School of Science and Engineering, Ibaraki University, 2-1-1, Bunkyo, Mito, Ibaraki 310-0056, Japan

Abstract

Abstract Synchrotron-radiation circular-dichroism spectroscopy was used to reveal that the DNA damage response induces a decrement of α-helix and an increment of β-strand contents of histone H3–H4 extracted from X-ray–irradiated human HeLa cells. The trend of the structural alteration was qualitatively opposite to that of our previously reported results for histone H2A–H2B. These results strongly suggest that histones share roles in DNA damage responses, particularly in DNA repair processes and chromatin remodeling, via a specific structural alteration of each histone.

Publisher

Oxford University Press (OUP)

Subject

Health, Toxicology and Mutagenesis,Radiology, Nuclear Medicine and imaging,Radiation

Link

http://academic.oup.com/jrr/article-pdf/58/1/59/33143724/rrw086.pdf

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