Cerebral histoplasmosis caused by Histoplasma capsulatum var. duboisii in a patient with no known immunodeficiency

Author:

Paccoud Olivier1,Nervo Marine2,Alanio Alexandre34,Garcia-Hermoso Dea4,Bougnoux Marie-Elisabeth5,Mateo Joaquim6,Mandonnet Emmanuel7,Lortholary Olivier14,Lanternier Fanny14,Adle-Biassette Homa2

Affiliation:

1. Department of Infectious Diseases and Tropical Medicine, Necker-Enfants Malades University Hospital, Assistance Publique des Hôpitaux de Paris (AP-HP), Paris University, Paris, France

2. Department of Pathology, Lariboisière University Hospital, AP-HP, Paris University, Paris, France

3. Department of Parasitology and Mycology, Saint-Louis University Hospital, AP-HP, Paris University, Paris, France

4. Molecular Mycology Unit, Centre National de la Recherche Scientifique (CNRS), Pasteur Institute, Paris, France

5. Department of Mycology, Necker-Enfants Malades University Hospital, AP-HP, Paris University, Paris, France

6. Department of Anesthesiology and Critical Care, Lariboisière University Hospital, AP-HP, Paris University, Paris, France

7. Department of Neurosurgery, Lariboisière University Hospital, AP-HP, Paris University, Paris, France

Abstract

We report the first case of central nervous system histoplasmosis caused by Histoplasma capsulatum var. duboisii in a patient with no underlying immunodeficiency. African histoplasmosis is an underdiagnosed endemic fungal infection which should be included in the differential diagnosis of cerebral lesions in patients originating from Western and Central Africa.

Publisher

Oxford University Press (OUP)

Subject

General Medicine

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