Dependent observations in clinical research-Reference-Cited by-同舟云学术

Dependent observations in clinical research

Published:2024-02-01 Issue:2 Volume:190 Page:E1-E3
ISSN:0804-4643
Container-title:European Journal of Endocrinology
language:en
Short-container-title:

Author:

Groenwold Rolf H H¹²^ORCID,Dekkers Olaf M¹³⁴^ORCID

Affiliation:

1. Department of Clinical Epidemiology, Leiden University Medical Center , Leiden , the Netherlands

2. Department of Biomedical Data Sciences, Leiden University Medical Center , Leiden , the Netherlands

3. Department of Clinical Epidemiology, Aarhus University and Aarhus University Hospital , Aarhus , Denmark

4. Department of Endocrinology, Leiden University Medical Center , Leiden , the Netherlands

Abstract

Abstract For many statistical methods that are commonly used in medical research, it is assumed that observations are independent. However, when this assumption is violated, alternative methods may be needed. In this paper, we describe why an analysis that ignores the dependencies within the data may provide biased results and outline possible alternatives. This paper aims to create awareness among researchers, readers, and reviewers for this possible source of bias in medical research.

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/ejendo/advance-article-pdf/doi/10.1093/ejendo/lvae014/56533714/lvae014.pdf

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