Protective Immunity and New Vaccines for Lyme Disease

Author:

Gomes-Solecki Maria1,Arnaboldi Paul M2,Backenson P Bryon3,Benach Jorge L4,Cooper Christopher L5,Dattwyler Raymond J2,Diuk-Wasser Maria6,Fikrig Erol7,Hovius J W8,Laegreid Will9,Lundberg Urban10,Marconi Richard T11,Marques Adriana R12,Molloy Philip13,Narasimhan Sukanya7,Pal Utpal14,Pedra Joao H F15,Plotkin Stanley16,Rock Daniel L17,Rosa Patricia18,Telford Sam R19,Tsao Jean2021,Yang X Frank22,Schutzer Steven E23

Affiliation:

1. Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Tennessee, USA

2. Department of Microbiology/Immunology, New York Medical College, New York, USA

3. New York State Department of Health, Albany, New York, USA

4. Department of Molecular Genetics and Microbiology, Stony Brook University, New York, USA

5. Molecular and Translational Sciences, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA

6. Department of Ecology, Evolution, and Environmental Biology, Columbia University, New York, USA

7. Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA

8. Department of Internal Medicine, Section of Infectious Diseases, Amsterdam Multidisciplinary Lyme Borreliosis Center, Amsterdam University Medical Centers, Academic Medical Center, The Netherlands

9. Department of Veterinary Sciences, Wyoming State Veterinary Laboratory, University of Wyoming, Laramie, Wyoming, USA

10. Valneva Austria GmbH, Vienna, Austria

11. Department of Microbiology and Immunology, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA

12. Lyme Disease Studies Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

13. Imugen, Norwood, Massachusetts, USA

14. Department of Veterinary Medicine, University of Maryland, College Park, Maryland, USA

15. Department of Microbiology and Immunology, University of Maryland School of Medicine, Maryland, USA

16. Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania, USA

17. College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Illinois, USA

18. Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA

19. Department of Infectious Disease and Global Health, Tufts University, North Grafton, Massachusetts, USA

20. Department of Fisheries and Wildlife, Michigan State University, East Lansing, Michigan, USA

21. Departments of Large Animal Clinical Sciences, Michigan State University, East Lansing, Michigan, USA

22. Department of Microbiology and Immunology, Indiana University of School of Medicine, Indianapolis, Indiana, USA

23. Department of Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, USA

Abstract

Abstract Lyme disease, caused by some Borrelia burgdorferi sensu lato, is the most common tick-borne illness in the Northern Hemisphere and the number of cases, and geographic spread, continue to grow. Previously identified B. burgdorferi proteins, lipid immunogens, and live mutants lead the design of canonical vaccines aimed at disrupting infection in the host. Discovery of the mechanism of action of the first vaccine catalyzed the development of new strategies to control Lyme disease that bypassed direct vaccination of the human host. Thus, novel prevention concepts center on proteins produced by B. burgdorferi during tick transit and on tick proteins that mediate feeding and pathogen transmission. A burgeoning area of research is tick immunity as it can unlock mechanistic pathways that could be targeted for disruption. Studies that shed light on the mammalian immune pathways engaged during tick-transmitted B. burgdorferi infection would further development of vaccination strategies against Lyme disease.

Funder

Steven and Alexandra Cohen Foundation

National Institutes of Health

Centers for Disease Control and Prevention

U.S. Biologic, Inc

European Commission

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

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