Concentrations and in vivo antibacterial activity of spiramycin and metronidazole in patients with periodontitis treated with high-dose metronidazole and the spiramycin/metronidazole combination

Author:

Poulet Pierre-Pascal,Duffaut Danielle,Barthet Pierre,Brumpt Ivan

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology,Microbiology (medical)

Reference10 articles.

1. Van Winkelhoff, A. J. & Van Der Reijden, W. A. (2000). Infections parodontales et implications thérapeutiques. Journal de Parodontologie & d'Implantologie orale19, 141–56.

2. Laufer, J., Mignon, H. & Videau, D. (1973). L'association métronidazole—spiramycine. Concentrations et synergie in situ comparées aux CMI de la flore buccale. Revue de Stomatologie et de Chirurgie maxillo-faciale74, 387–92.

3. Quee, T. C., Chan, E. C., Clark, C. et al. (1987). The role of adjunctive Rodogyl therapy in the treatment of advanced periodontal disease. A longitudinal clinical and microbiologic study. Journal of Periodontology58, 594–601.

4. Loesche, W. J., Schmidt, E., Smith, W. J. et al. (1992). Effects of metronidazole on periodontal treatment needs. Journal of Periodontology62, 247–57.

5. Rotzetter, P. A., Le Liboux, A., Pichard, E. et al. (1994). Kinetics of spiramycin/metronidazole (Rodogyl) in human gingival crevicular fluid, saliva and blood. Journal of Clinical Periodontology21, 595–600.

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