Impact of an Integrated Antibiotic Allergy Testing Program on Antimicrobial Stewardship: A Multicenter Evaluation

Author:

Trubiano Jason A123,Thursky Karin A245,Stewardson Andrew J1,Urbancic Karen156,Worth Leon J25,Jackson Cheryl7,Stevenson Wendy18,Sutherland Michael8,Slavin Monica A25,Grayson M Lindsay13,Phillips Elizabeth J910

Affiliation:

1. Department of Infectious Diseases, Austin Health, Heidelberg,

2. Department of Infectious Diseases, Peter MacCallum Cancer Centre, Victoria Comprehensive Cancer Centre (VCCC)

3. Department of Medicine, University of Melbourne, Parkville,

4. National Centre for Antimicrobial Stewardship, Royal Melbourne Hospital,

5. Centre for Improving Cancer Outcomes Through Enhanced Infection Services, National Health and Medical Research Council Centre of Research Excellence, Sir Peter MacCallum Department of Oncology, University of Melbourne,

6. Department of Pharmacy, Austin Health, Heidelberg,

7. Department of Pharmacy, Peter MacCallum Cancer Centre, VCCC, Parkville, and

8. Department of Respiratory and Sleep Medicine, Austin Health, Heidelberg, Victoria, and

9. Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Western Australia, Australia; and

10. Departments of Medicine and Pharmacology, Vanderbilt University Medical Centre, Nashville, Tennessee

Abstract

Summary An integrated antibiotic allergy testing program resulted in increased prescribing of narrow-spectrum β-lactams and reduction in restricted antibiotics and inappropriate prescriptions. The program effectively and safely de-labeled patients, with >80% of antibiotic allergy labels removed following testing.

Funder

National Institutes of Health

National Health and Medical Research Council

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

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