Differentiated Care Pathways for Antiretroviral Therapy Monitoring in Malawi: Expanding Viral Load Testing in Setting of Highly Prevalent Resistance-Reference-Cited by-同舟云学术

Differentiated Care Pathways for Antiretroviral Therapy Monitoring in Malawi: Expanding Viral Load Testing in Setting of Highly Prevalent Resistance

Published:2017 Issue:3 Volume:4 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Rutstein Sarah E¹²,Compliment Kara³⁴,Nelson Julie A E³⁴,Kamwendo Deborah⁵,Mataya Ronald⁶,Miller William C²⁷,Hosseinipour Mina C²⁵

Affiliation:

1. Department of Health Policy and Management, University of North Carolina at Chapel Hill

2. Division of Infectious Diseases, University of North Carolina at Chapel Hill

3. UNC Center for AIDS Research, University of North Carolina at Chapel Hill

4. Department of Microbiology and Immunology, University of North Carolina at Chapel Hill

5. UNC Project, Lilongwe, Malawi

6. School of Public Health, Loma Linda University, California

7. Department of Epidemiology, University of North Carolina at Chapel Hill

Abstract

Abstract We quantified resistance to first-line antiretroviral therapy among previously unmonitored patients in Malawi with viremia (≥1000 copies/mL). Ninety-five percent (n = 57/61) harbored nucleoside/tide reverse transcriptase inhibitor/non-nucleoside reverse transcriptase inhibitor resistance; resistance was more common comparing >2 (97%) versus ≤2 years (87%) on therapy. Immediate switch for persons retained in care may improve monitoring efficiency and maximize clinical outcomes.

Funder

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Link

http://academic.oup.com/ofid/article-pdf/4/3/ofx125/33622917/ofx125.pdf

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