Disease Severity and Effective Parasite Multiplication Rate in Falciparum Malaria-Reference-Cited by-同舟云学术

Disease Severity and Effective Parasite Multiplication Rate in Falciparum Malaria

Published:2017 Issue:4 Volume:4 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Kingston Hugh W¹²³,Ghose Aniruddha⁴,Plewes Katherine¹³,Ishioka Haruhiko¹,Leopold Stije J¹³,Maude Richard J¹³,Paul Sanjib⁴,Intharabut Benjamas¹,Silamut Kamorat¹,Woodrow Charles¹³^ORCID,Day Nicholas P J¹³,Chotivanich Kesinee¹,Anstey Nicholas M²,Hossain Amir⁴,White Nicholas J¹³,Dondorp Arjen M¹³

Affiliation:

1. Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

2. Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia

3. Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, Churchill Hospital, Oxford, United Kingdom

4. Chittagong Medical College, Chittagong, Bangladesh

Abstract

Abstract Patients presenting with severe falciparum malaria in a Bangladeshi tertiary hospital had higher total parasite burden, estimated by parasitemia and plasma PfHRP2, than uncomplicated malaria patients despite shorter fever duration. This suggests that higher parasite multiplication rates (PMR) contribute to causing the higher biomass found in severe disease. Compared with patients without a history of previous malaria, patients with previous malaria carried a lower parasite biomass with similar fever duration at presentation, suggesting that host immunity reduces the PMR.

Funder

Wellcome Trust

National Health and Medical Research Council

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Link

http://academic.oup.com/ofid/article-pdf/4/4/ofx169/33623953/ofx169.pdf

Reference15 articles.

1. Acquired immunity to malaria;Doolan;Clin Microbiol Rev,2009

2. Malaria;White;Lancet,2014