Pulmonary Histoplasma Infection After Allogeneic Hematopoietic Stem Cell Transplantation: Case Report and Review of the Literature

Author:

Natarajan Mukil1,Swierzbinski Matthew J.1,Maxwell Sandra2,Zelazny Adrian M.3,Fahle Gary A.3,Quezado Martha4,Barrett John2,Battiwalla Minoo2,Lionakis Michail S.1

Affiliation:

1. Fungal Pathogenesis Unit, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, Maryland

2. Stem Cell Allogeneic Transplantation Section, Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland

3. Microbiology Service, Department of Laboratory Medicine, NIH Clinical Center, Bethesda, Maryland; and

4. Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland

Abstract

Abstract Histoplasmosis causes a wide spectrum of clinical illness, including disseminated infection in the immunocompromised. We report a case of pulmonary histoplasmosis in an allogeneic stem cell transplant recipient and review the literature on this topic. Histoplasmosis in this patient population is uncommon, but it is associated with poor outcome.

Funder

National Institute of Allergy and Infectious Diseases

National Heart, Lung, and Blood Institute

National Cancer Institute

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

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