A population-based study of Helicobacter pylori: Does asymptomatic infection mean no gastroscopic lesions?

Author:

Cai Ting12,Li Ying3,Li Xin-meng12,Chen Bing12,Liang Lun-xi14,Yuan Ling-zhi12,Hu Hai5,Zhang Ming-lin12,Deng Ao-jian12,Liu Xiao-ming12,Wang Fen12ORCID

Affiliation:

1. Department of Gastroenterology, The Third Xiangya Hospital, Central South University , 138 Tongzipo Road, Changsha, Hunan 410013 , China

2. Hunan Key Laboratory of Nonresolving Inflammation and Cancer, The Third Xiangya Hospital, Central South University , 138 Tongzipo Road, Changsha, Hunan 410013 , China

3. Health Management Center, The Third Xiangya Hospital, Central South University , 138 Tongzipo Road, Changsha, Hunan 410013 , China

4. Hunan Key Laboratory of Nonresolving Inflammation and Cancer, The Third Xiangya Hospital, Central South University , 138 Tongzipo Road, Changsha, Hunan 410013, China

5. Department of Orthopedics, The Third Xiangya Hospital, Central South University , 138 Tongzipo Road, Changsha, Hunan 410013 , China

Abstract

Abstract Objectives We determined the common clinical characteristics of patients infected with Helicobacter pylori (H. pylori) and investigated the relationship between H. pylori infection, and clinical symptoms, and gastroscopic manifestations. Our focus was specifically on the clinical manifestations in asymptomatic patients. Methods We obtained the physical examination data of patients who underwent the 14C urea breath test between January 2018 and December 2020 at our Hospital. Basic demographic data, questionnaire data on clinical symptoms, and clinical examination data of the patients were also collected, and the correlation analysis was performed. Results A total of 2863 participants were included in the study. The overall H. pylori infection rate was 26.30%. The clinical symptoms between H. pylori-positive patients and H. pylori-negative patients did not differ significantly (P > .05). However, H. pylori-positive patients exhibited more severe gastroscopic manifestations (P < .001). The 14C urea breath test disintegrations per minute (DPM) values in H. pylori-positive patients correlated with their serum pepsinogen and gastrin-17 levels. With an increase in the DPM value, more combinations of clinical symptoms appeared in the patients. Among H. pylori-positive patients, DPM levels in asymptomatic patients were lower than those in symptomatic patients (P < .001). However, gastroscopic manifestations did not vary significantly between asymptomatic and symptomatic patients (P > .05). Conclusion Patients infected with H. pylori showed no specific gastrointestinal symptoms. Patients with asymptomatic infection showed lower DPM levels, but their gastroscopic manifestations were similar to those of patients with symptomatic infection, and their lesions were more severe than H. pylori-negative people.

Funder

National Natural Science Foundation of China

National Natural Science Foundation for Youths of China

Scientific Research Project of Hunan Provincial Health Commission

Hunan Provincial Natural Science Foundation of China for Youths

Publisher

Oxford University Press (OUP)

Subject

General Medicine

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