L-shaped association between dietary zinc intake and cognitive decline in Chinese older people

Author:

Meng Qiguo12345ORCID,Liu Mengyi123,Zu Cheng45,Su Xinyue45,Wei Yuanxiu45,Gan Xiaoqin123,Zhang Yuanyuan123,He Panpan123,Zhou Chun123,Ye Ziliang123,Liu Chengzhang45,Qin Xianhui12345ORCID

Affiliation:

1. Nanfang Hospital, Southern Medical University Division of Nephrology, ; National Clinical Research Center for Kidney Disease; ; , Guangzhou, Guangdong 510515, China

2. State Key Laboratory of Organ Failure Research Division of Nephrology, ; National Clinical Research Center for Kidney Disease; ; , Guangzhou, Guangdong 510515, China

3. Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou Regenerative Medicine and Health Guangdong Laboratory Division of Nephrology, ; National Clinical Research Center for Kidney Disease; ; , Guangzhou, Guangdong 510515, China

4. Anhui Medical University Department of Epidemiology and Biostatistics, School of Public Health, , Hefei, Anhui 230032, China

5. Anhui Medical University Institute of Biomedicine, , Hefei, Anhui 230032, China

Abstract

Abstract Background and Objective The prospective association between dietary zinc (Zn) intake and cognitive decline remains uncertain. We aimed to assess the relationship of dietary Zn intake with the risk of cognitive decline in the Chinese older people, and examine the possible effect modifiers on this association. Methods A total of 3,106 older Chinese adults aged 55 years or older from China Health and Nutrition Survey were included. Dietary nutrients intake information was collected by combined 24-h dietary recalls with weighing food inventory. The cognitive decline was defined as the 5-year decline rate in global and composite cognitive scores, based on a subset of items from the Telephone Interview for Cognitive Status–modified. Results The median follow-up duration was 5.9 years. There was an L-shaped association between dietary Zn intake and the 5-year decline rates in global and composite cognitive scores, with an inflection point at 8.8 mg/day of dietary Zn. For the composite cognitive scores, compared with the first quantile (<7.9 mg/day) of dietary Zn intake, quantiles 2–6 (≥7.9 mg/day) had a significantly slower cognitive decline rate (β: −0.24; 95% confidence interval: −0.40 to −0.07). Similar results were found for the global cognitive scores. Moreover, the inverse association between dietary Zn intake and cognitive decline in composite cognitive scores was significantly stronger in those with lower levels of physical activity (P-interactions = 0.041). Conclusion Dietary Zn intake was negatively associated with cognitive decline in the older people. Maintaining appropriate dietary Zn levels may prevent cognitive decline.

Funder

National Natural Science Foundation of China

National Key Research and Development Program

Publisher

Oxford University Press (OUP)

Subject

Geriatrics and Gerontology,Aging,General Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3