Affiliation:
1. University of Helsinki, Clinicum, and Helsinki University Hospital, Helsinki, Finland
2. Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland
3. Department of Epidemiology and Public Health, University College London, London, UK
4. University of Oulu, Center for Life Course Health Research, Oulu, Finland
Abstract
Abstract
Background
statin treatment has increased also among people aged 80 years and over, but adverse effects potentially promoting frailty and loss of resilience are frequent concerns.
Methods
in the Helsinki Businessmen Study, men born in 1919–34 (original n = 3,490) have been followed up since the 1960s. In 2011, a random subcohort of home-living survivors (n = 525) was assessed using questionnaires and clinical (including identification of phenotypic frailty) and laboratory examinations. A 7-year mortality follow-up ensued.
Results
we compared 259 current statin users (median age 82 years, interquartile range 80–85 years) with 266 non-users (83; 80–86 years). Statin users had significantly more multimorbidity than non-users (prevalencies 72.1% and 50.4%, respectively, P < 0.0001) and worse glucose status than non-users (prevalencies of diabetes 19.0% and 9.4%, respectively, P = 0.0008). However, there was no difference in phenotypic frailty (10.7% versus 11.2%, P = 0.27), and statin users had higher plasma prealbumin level than non-users (mean levels 257.9 and 246.3 mg/L, respectively, P = 0.034 adjusted for age, body mass index and C-reactive protein) implying better nutritional status. Despite morbidity difference, age-adjusted 7-year mortality was not different between the two groups (98 and 103 men among users and non-users of statins, respectively, hazard ratio 0.96, 95% confidence interval 0.72–1.30).
Conclusions
our study suggests that male octogenarian statin users preserved resilience and survival despite multimorbidity, and this may be associated with better nutritional status among statin users.
Funder
Helsinki University Central Hospital
Academy of Finland
Medical Research Council
National Institute on Aging
Publisher
Oxford University Press (OUP)
Subject
Geriatrics and Gerontology,Ageing,General Medicine
Cited by
6 articles.
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