Postdischarge functional outcomes in older patients with acute heart failure in Japan: the Longevity Improvement & Fair Evidence study

Author:

Narii Nobuhiro1,Kitamura Tetsuhisa1ORCID,Hirayama Atsushi2,Shimomura Yoshimitsu1,Zha Ling1,Komatsu Masayo1,Komukai Sho3,Sotomi Yohei4,Okada Katsuki45,Sakata Yasushi4,Murata Fumiko6,Maeda Megumi6,Kiyohara Kosuke7,Sobue Tomotaka1,Fukuda Haruhisa6

Affiliation:

1. Osaka University Environmental Medicine and Population Sciences, Department of Social and Environmental Medicine, Graduate School of Medicine, , Suita, Osaka, Japan

2. Osaka University Public Health, Department of Social Medicine, Graduate School of Medicine, , Suita, Osaka, Japan

3. Osaka University Biomedical Statistics, Department of Integrated Medicine, Graduate School of Medicine, , Suita, Osaka, Japan

4. Osaka University Department of Cardiovascular Medicine, Graduate School of Medicine, , Suita, Osaka, Japan

5. Osaka University Medical Informatics, Department of Integrated Medicine, Graduate School of Medicine, , Suita, Osaka, Japan

6. Kyushu University Graduate School of Medical Sciences Department of Health Care Administration and Management, , Fukuoka, Fukuoka, Japan

7. Otsuma Women’s University Department of Food Science, Faculty of Home Economics, , Tokyo, Japan

Abstract

Abstract Background The association between care needs level (CNL) at hospitalisation and postdischarge outcomes in older patients with acute heart failure (aHF) has been insufficiently investigated. Methods This population-based cohort study was conducted using health insurance claims and CNL data of the Longevity Improvement & Fair Evidence study. Patients aged ≥65 years, discharged after hospitalisation for aHF between April 2014 and March 2022, were identified. CNLs at hospitalisation were classified as no care needs (NCN), support level (SL) and CNL1, CNL2–3 and CNL4–5 based on total estimated daily care time as defined by national standard criteria, and varied on an ordinal scale between SL&CNL1 (low level) to CNL4–5 (fully dependent). The primary outcomes were changes in CNL and death 1 year after discharge, assessed by CNL at hospitalisation using Cox proportional hazard models. Results Of the 17 724 patients included, 7540 (42.5%), 4818 (27.2%), 3267 (18.4%) and 2099 (11.8%) had NCN, SL&CNL1, CNL2–3 and CNL4–5, respectively, at hospitalisation. One year after discharge, 4808 (27.1%), 3243 (18.3%), 2968 (16.7%), 2505 (14.1%) and 4200 (23.7%) patients had NCN, SL&CNL1, CNL2–3, CNL4–5 and death, respectively. Almost all patients’ CNLs worsened after discharge. Compared to patients with NCN at hospitalisation, patients with SL&CNL1, CNL2–3 and CNL4–5 had an increased risk of all-cause death 1 year after discharge (hazard ratio [95% confidence interval]: 1.19 [1.09–1.31], 1.88 [1.71–2.06] and 2.56 [2.31–2.84], respectively). Conclusions Older patients with aHF and high CNL at hospitalisation had a high risk of all-cause mortality in the year following discharge.

Funder

Osaka University Graduate School of Medicine

JST FOREST Programme

Japan Society for the Promotion of Science

Publisher

Oxford University Press (OUP)

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