STOPPFall (Screening Tool of Older Persons Prescriptions in older adults with high fall risk): a Delphi study by the EuGMS Task and Finish Group on Fall-Risk-Increasing Drugs

Author:

Seppala Lotta J1,Petrovic Mirko2,Ryg Jesper3,Bahat Gulistan4,Topinkova Eva5,Szczerbińska Katarzyna6,van der Cammen Tischa J M7,Hartikainen Sirpa8,Ilhan Birkan9,Landi Francesco10,Morrissey Yvonne11,Mair Alpana12,Gutiérrez-Valencia Marta13,Emmelot-Vonk Marielle H14,Mora María Ángeles Caballero15,Denkinger Michael16,Crome Peter17,Jackson Stephen H D18,Correa-Pérez Andrea19,Knol Wilma20,Soulis George21,Gudmundsson Adalsteinn22,Ziere Gijsbertus23,Wehling Martin24,O’Mahony Denis25,Cherubini Antonio26,van der Velde Nathalie1

Affiliation:

1. Department of Internal Medicine, Section of Geriatric Medicine, Amsterdam Public Health Research Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

2. Department of Internal Medicine and Paediatrics (section of Geriatrics), Ghent University, Ghent, Belgium

3. Department of Geriatric Medicine, Odense University Hospital, Odense, Denmark and Geriatric Research Unit, Department of Clinical Research, University of Southern Denmark, Odense, Denmark

4. Istanbul Medical School, Department of Internal Medicine, Division of Geriatrics, Istanbul University, Capa, Istanbul, Turkey

5. Department of Geriatrics and Gerontology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic and Faculty of Health and Social Sciences, South Bohemian University, Česke Budějovice, Czech Republic

6. Laboratory for Research on Aging Society, Department of Sociology of Medicine, Epidemiology and Preventive Medicine Chair, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland

7. Faculty of Industrial Design Engineering, Delft University of Technology, Delft, The Netherlands

8. School of Pharmacy, University of Eastern Finland, Kuopio, Finland

9. Division of Geriatrics, Department of Internal Medicine, Şişli Hamidiye Etfal Training and Research Hospital, University of Medical Sciences, Istanbul, Turkey

10. Department of Gerontology, Neuroscience and Orthopedics, Catholic University of the Sacred Heart, Rome, Italy

11. Health Care of Older People, East Kent Hospitals University NHS Foundation Trust, Canterbury, Kent, UK

12. Effective Prescribing and Therapeutics, Health and Social Care Directorate, Scottish Government, Edinburgh, Scotland, UK

13. Unit of Innovation and Organization, Navarre Health Service, Pamplona, Spain

14. Department of Geriatrics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands

15. Servicio de Geriatría, Hospital General Universitario de Ciudad Real and CIBER de Fragilidad y Envejecimiento Saludable, Spain

16. Agaplesion Bethesda Clinic, Geriatric Research Unit Ulm University and Geriatric Centre Ulm, Ulm, Germany

17. Research Department of Primary Care and Population Health, University College London, London, UK

18. Department of Clinical Gerontology, King's College, London, England, UK

19. Servicio de Geriatría, Hospital Universitario Ramón y Cajal (IRYCIS), Madrid, Spain

20. Department of Geriatric Medicine and Expertise Centre Pharmacotherapy in Old Persons, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands

21. Outpatient Geriatric Assessment Unit, Henry Dunant Hospital Center, Athens, Greece

22. Landspitali University Hospital, Iceland and Faculty of Medicine, University of Iceland, Reykjavik, Iceland

23. Department of Internal Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands and Department of Epidemiology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands

24. Institute for Clinical Pharmacology, Medical Faculty Mannheim, Ruprecht-Karls-University Heidelberg, Germany

25. Department of Geriatric Medicine, Cork University Hospital, Cork, Ireland and Department of Medicine, University College Cork, Cork, Ireland

26. Geriatria, Accettazione Geriatrica e Centro di ricerca per l'invecchiamento, IRCCS INRCA, Ancona, Italy

Abstract

Abstract Background Healthcare professionals are often reluctant to deprescribe fall-risk-increasing drugs (FRIDs). Lack of knowledge and skills form a significant barrier and furthermore, there is no consensus on which medications are considered as FRIDs despite several systematic reviews. To support clinicians in the management of FRIDs and to facilitate the deprescribing process, STOPPFall (Screening Tool of Older Persons Prescriptions in older adults with high fall risk) and a deprescribing tool were developed by a European expert group. Methods STOPPFall was created by two facilitators based on evidence from recent meta-analyses and national fall prevention guidelines in Europe. Twenty-four panellists chose their level of agreement on a Likert scale with the items in the STOPPFall in three Delphi panel rounds. A threshold of 70% was selected for consensus a priori. The panellists were asked whether some agents are more fall-risk-increasing than others within the same pharmacological class. In an additional questionnaire, panellists were asked in which cases deprescribing of FRIDs should be considered and how it should be performed. Results The panellists agreed on 14 medication classes to be included in the STOPPFall. They were mostly psychotropic medications. The panellists indicated 18 differences between pharmacological subclasses with regard to fall-risk-increasing properties. Practical deprescribing guidance was developed for STOPPFall medication classes. Conclusion STOPPFall was created using an expert Delphi consensus process and combined with a practical deprescribing tool designed to optimise medication review. The effectiveness of these tools in falls prevention should be further evaluated in intervention studies.

Funder

Clementine Brigitta Maria Dalderup fund

Amsterdam Public Health Aging and Later Life Innovation Price

Publisher

Oxford University Press (OUP)

Subject

Geriatrics and Gerontology,Ageing,General Medicine

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