1. Division of Population Medicine, Cardiff University, School of Medicine, Neuadd Meirionnydd, Heath Park, Cardiff, UK
2. Department of Geriatric Medicine, University Hospital Llandough, Cardiff, UK
3. Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
4. D3B Early phase trials unit, Institute of Translational Medicine, Birmingham, UK
5. Department of General Surgery, North Bristol NHS Trust, Bristol, UK
6. Academic Unit of Elderly Care & Rehabilitation, University of Leeds, Bradford Teaching Hospitals NHS Foundation Trust, Duckworth Lane, Bradford, UK