1. Musculoskeletal Research Unit , Translational Health Sciences, Bristol Medical School, 1st Floor Learning & Research Building, Southmead Hospital, Bristol BS10 5NB , UK
2. Department of Trauma and Orthopaedic Surgery , Southmead Hospital, Bristol BS10 5NB , UK
3. National Institute for Health Research Bristol Biomedical Research Centre , University Hospitals Bristol NHS Foundation Trust and University of Bristol, Bristol, UK