1. Medical Sciences Division, University of Oxford , Oxford OX3 9DU , UK
2. Centre for Evidence-Based Medicine , Nuffield Department of Primary Care Health Sciences, , Radcliffe Observatory Quarter, Woodstock Road, Oxford OX2 6GG , UK
3. University of Oxford , Nuffield Department of Primary Care Health Sciences, , Radcliffe Observatory Quarter, Woodstock Road, Oxford OX2 6GG , UK
4. Oxford University Hospitals NHS Trust , Oxford OX3 9DU , UK