Moderate physical activity associated with a higher naïve/memory T-cell ratio in healthy old individuals: potential role of IL15

Author:

Bartlett David B1,Duggal Niharika A2

Affiliation:

1. Department of Medicine, Division of Medical Oncology, Duke University, Durham, NC 27701, USA

2. MRC-Arthritis Research UK Centre for Musculoskeletal Ageing Research, Institute of Inflammation and Ageing, Birmingham University, Birmingham B15 2TT, UK

Abstract

Abstract Introduction ageing is accompanied by impairments in immune responses due to remodelling of the immune system (immunesenescence). Additionally, a decline in habitual physical activity has been reported in older adults. We have recently published that specific features of immunesenescence, such as thymic involution and naïve/memory T-cell ratio, are prevented by maintenance of a high level of physical activity. This study compares immune ageing between sedentary and physically active older adults. Methods a cross-sectional study recruited 211 healthy older adults (60–79 years) and assessed their physical activity levels using an actigraph. We compared T- and B-cell immune parameters between relatively sedentary (n = 25) taking 2,000–4,500 steps/day and more physically active older adults (n = 25) taking 10,500–15,000 steps/day. Results we found a higher frequency of naïve CD4 (P = 0.01) and CD8 (P = 0.02) and a lower frequency of memory CD4 cells (P = 0.01) and CD8 (P = 0.04) T cells in the physically active group compared with the sedentary group. Elevated serum IL7 (P = 0.03) and IL15 (P = 0.003), cytokines that play an essential role in T-cell survival, were seen in the physically active group. Interestingly, a positive association was observed between IL15 levels and peripheral CD4 naïve T-cell frequency (P = 0.023). Discussion we conclude that a moderate level of physical activity may be required to give a very broad suppression of immune ageing, though 10,500–15,000 steps/day has a beneficial effect on the naïve T-cell pool.

Funder

Biotechnology and Biological Sciences Research Council

Publisher

Oxford University Press (OUP)

Subject

Geriatrics and Gerontology,Aging,General Medicine

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