Long-term beneficial impact of the randomised trial ‘Train the Brain’, a motor/cognitive intervention in mild cognitive impairment people: effects at the 14-month follow-up
Author:
Sale Alessandro1, Noale Marianna2, Cintoli Simona3, Tognoni Gloria3, Braschi Chiara1, Berardi Nicoletta145, Maggi Stefania2, Maffei Lamberto1, Maffei L, Picano E, Andreassi M G, Angelucci A, Baldacci F, Baroncelli L, Begenisic T, Bellinvia P F, Berardi N, Biagi L, Bonaccorsi J, Bonanni E, Bonuccelli U, Borghini A, Braschi C, Broccardi M, Bruno R M, Caleo M, Carlesi C, Carnicelli L, Cartoni G, Cecchetti L, Cenni M C, Ceravolo R, Chico L, Cintoli S, Cioni G, Coscia M, Costa M, D’Angelo G, D’Ascanio P, De Nes M, Del Turco S, Di Coscio E, Di Galante M, di Lascio N, Faita F, Falorni I, Faraguna U, Fenu A, Fortunato L, Franco R, Gargani L, Gargiulo R, Ghiadoni L, Giorgi F S, Iannarella R, Iofrida C, Kusmic C, Limongi F, Maestri M, Maffei M, Maggi S, Mainardi M, Mammana L, Marabotti A, Mariotti V, Melissari E, Mercuri A, Micera S, Molinaro S, Narducci R, Navarra T, Noale M, Pagni C, Palumbo S, Pasquariello R, Pellegrini S, Pietrini P, Pizzorusso T, Poli A, Pratali L, Retico A, Ricciardi E, Rota G, Sale A, Sbrana S, Scabia G, Scali M, Scelfo D, Sicari R, Siciliano G, Stea F, Taddei S, Tognoni G, Tonacci A, Tosetti M, Turchi S, Volpi L,
Affiliation:
1. Neuroscience Institute CNR (National Research Council) , Via Moruzzi 1, Pisa 56124, Italy 2. Neuroscience Institute CNR (National Research Council) , Via Giustiniani 2, Padua 35128, Italy 3. Department of Clinical and Experimental Medicine-Neurology Unit, University of Pisa and AOU Pisa , Pisa, Italy 4. Department of Neuroscience , Psychology, Drug Research and Child Health, , Via San Salvi, Florence 50100, Italy 5. Florence University , Psychology, Drug Research and Child Health, , Via San Salvi, Florence 50100, Italy
Abstract
Abstract
No treatment options are currently available to counteract cognitive deficits and/or delay progression towards dementia in older people with mild cognitive impairment (MCI). The ‘Train the Brain’ programme is a combined motor and cognitive intervention previously shown to markedly improve cognitive functions in MCI individuals compared to non-trained MCI controls, as assessed at the end of the 7-month intervention. Here, we extended the previous analyses to include the long-term effects of the intervention and performed a data disaggregation by gender, education and age of the enrolled participants. We report that the beneficial impact on cognitive functions was preserved at the 14-month follow-up, with greater effects in low-educated compared to high-educated individuals, and in women than in men.
Publisher
Oxford University Press (OUP)
Subject
Geriatrics and Gerontology,Aging,General Medicine
Cited by
5 articles.
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