1. Royal Derby Hospital Department of General Surgery, , Derby DE22 3NE , UK
2. Centre of Metabolism, Ageing & Physiology, School of Medicine, University of Nottingham, Royal Derby Hospital Centre , Derby, DE22 3DT , UK
3. Nottingham NIHR Biomedical Research Centre , Nottingham, NG7 2RD , UK
4. MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research, Universities of Nottingham and Birmingham , UK
5. Royal Derby Hospital Department of Anaesthetics, , Derby DE22 3NE , UK
6. MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research , Universities of Nottingham and Birmingham, UK
7. Centre of Metabolism, Ageing & Physiology, School of Medicine, University of Nottingham , Royal Derby Hospital Centre, Derby, DE22 3DT , UK