Structural basis for the synergy of 4′- and 2′-modifications on siRNA nuclease resistance, thermal stability and RNAi activity
Author:
Affiliation:
1. Department of Biochemistry, Vanderbilt University, School of Medicine, Nashville, TN 37232, USA
2. Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA
Funder
Alnylam Pharmaceuticals
Vanderbilt University
National Institutes of Health
Publisher
Oxford University Press (OUP)
Subject
Genetics
Link
http://academic.oup.com/nar/article-pdf/46/16/8090/25802822/gky703.pdf
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