SPOP promotes transcriptional expression of DNA repair and replication factors to prevent replication stress and genomic instability

Author:

Hjorth-Jensen Kim12,Maya-Mendoza Apolinar3,Dalgaard Nanna12,Sigurðsson Jón O4,Bartek Jiri35,Iglesias-Gato Diego12ORCID,Olsen Jesper V4,Flores-Morales Amilcar124

Affiliation:

1. Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

2. Translational Cancer Research Unit, Danish Cancer Society Research Center, Copenhagen, Denmark

3. Genome Integrity Unit, Danish Cancer Society Research Center, Copenhagen, Denmark

4. Novo Nordisk Foundation Center for Protein Research, Department of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

5. Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Science for Life Laboratory, Karolinska Institute, Stockholm, Sweden

Funder

Danish Research Council

Danish Cancer Society

Novo Nordisk Foundation

Publisher

Oxford University Press (OUP)

Subject

Genetics

Reference49 articles.

1. Punctuated evolution of prostate cancer genomes;Baca;Cell,2013

2. Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer;Barbieri;Nat. Genet.,2012

3. Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes;Le Gallo;Nat. Genet.,2012

4. Prostate cancer. Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer;Theurillat;Science,2014

5. Truncated ERG oncoproteins from TMPRSS2-ERG fusions are resistant to SPOP-mediated proteasome degradation;An;Mol. Cell,2015

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