The need for good practice in the application of mechanistic constructs in hazard and risk assessment

Author:

Meek M E (Bette)12ORCID,Wikoff Daniele3ORCID

Affiliation:

1. McLaughlin Centre for Population Health Risk Assessment, University of Ottawa , Ottawa, Ontario K1G 5Z3, Canada

2. School of Epidemiology and Public Health, University of Ottawa , Ottawa, Ontario K1G 5Z3, Canada

3. ToxStrategies, Inc , Asheville, North Carolina 28801, USA

Abstract

Abstract A series of recent and proposed workshops address the interface between key characteristics and mechanistic pathway descriptions (adverse outcome pathways and mode of action) to identify commonalities and potential for complementary application. Informed by different communities, these constructs have collective potential to increase confidence to support the application of mechanistic data in hazard assessment. This forum article summarizes concepts, introduces evolving understanding, and invites future collaboration to contribute to better common understanding and development of good practice in the use of mechanistic data in hazard assessment.

Publisher

Oxford University Press (OUP)

Subject

Toxicology

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3. Consensus on the key characteristics of immunotoxic agents as a basis for hazard identification;Germolec;Environ. Health Perspect,2022

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