Long-term AZT Exposure Alters the Metabolic Capacity of Cultured Human Lymphoblastoid Cells

Author:

Olivero Ofelia A.,Vazquez Irma L.,Cooch Catherine C.,Ming Jessica,Keller Emily,Yu Mia,Borojerdi Jennifer P.,Braun Hannan M.,McKee Edward,Poirier Miriam C.

Publisher

Oxford University Press (OUP)

Subject

Toxicology

Reference40 articles.

1. Genotoxicity and mitochondrial damage in human lymphocytic cells chronically exposed to 3′-azido-2′,3′-dideoxythymidine (AZT);Mutat. Res.,1997

2. Long-term exposure to zidovudine affects in vitro and in vivo the efficiency of phosphorylation of thymidine kinase;AIDS Res. Hum. Retroviruses,1996

3. Selective assays for thymidine kinase 1 and 2 and deoxycytidine kinase and their activities in extracts from human cells and tissues;Biochem. Biophys. Res. Commun.,1992

4. Azidothymidine induces dose dependent increase in micronuclei formation in cultured HeLa cells;Pharmazie,2001

5. Evidence of in vitro development of drug resistance to azidothymidine in T-lymphocytic leukemia cell lines (Jurkat E6-1/AZT-100) and in pediatric patients with HIV-1 infection;J. Acquir. Immune Defic. Syndr.,1993

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