Human 3D Gastrointestinal Microtissue Barrier Function As a Predictor of Drug-Induced Diarrhea-Reference-Cited by-同舟云学术

Human 3D Gastrointestinal Microtissue Barrier Function As a Predictor of Drug-Induced Diarrhea

Published:2018-10-26 Issue:1 Volume:168 Page:3-17
ISSN:1096-6080
Container-title:Toxicological Sciences
language:en
Short-container-title:

Author:

Peters Matthew F¹,Landry Tim²,Pin Carmen³,Maratea Kim¹,Dick Cortni¹,Wagoner Matthew P¹,Choy Allison L⁴,Barthlow Herb¹,Snow Deb¹,Stevens Zachary²,Armento Alex²,Scott Clay W¹,Ayehunie Seyoum²

Affiliation:

1. Oncology Safety, Drug Safety and Metabolism, IMED Biotech Unit, AstraZeneca, Waltham, MA 02451

2. MatTek Corporation, Ashland, Massachusetts 01721

3. Mechanistic Safety and ADME Sciences, Drug Safety and Metabolism, IMED Biotech Unit, AstraZeneca, Cambridge, CB4 0WG, UK

4. Science and Enabling Units IT, AstraZeneca, Waltham, MA 02451

Funder

AstraZeneca and MatTek

National Institute of General Medical Sciences

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Toxicology

Link

http://academic.oup.com/toxsci/article-pdf/168/1/3/27981900/kfy268.pdf

Reference51 articles.

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2. Drug-induced, factitious, & idiopathic diarrhoea;Abraham;Best Pract. Res. Clin. Gastroenterol,2012

3. Gastrointestinal safety pharmacology in drug discovery and development;Al-Saffar;Handb. Exp. Pharmacol,2015

4. Phase I pharmacokinetic and pharmacodynamic study of the prenyl transferase inhibitor AZD3409 in patients with advanced cancer;Appels;Br. J. Cancer,2008

5. Human primary cell-based organotypic microtissues for modeling small intestinal drug absorption;Ayehunie;Pharm. Res,2018

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