Cigarette Smoke Toxins-Induced Mitochondrial Dysfunction and Pancreatitis Involves Aryl Hydrocarbon Receptor Mediated Cyp1 Gene Expression: Protective Effects of Resveratrol

Author:

Ghosh Jyotirmoy12,Chowdhury Anindya Roy1,Srinivasan Satish13,Chattopadhyay Mrittika1,Bose Moumita14,Bhattacharya Sabyasachi13,Raza Haider5,Fuchs Serge Y1,Rustgi Anil K6,Gonzalez Frank J7,Avadhani Narayan G18

Affiliation:

1. Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104

2. Department of Chemistry, Banwarilal Bhalotia College, Asansol, Ushagram, Asansol-713303, West Bengal, India

3. Roche Molecular Systems, 1080, US-202, Branchburg, NJ 08876

4. Department of Internal Medicine, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390

5. Department of Biochemistry, College of Medicine and Health Sciences, UAE University, Al-Ain, UAE

6. Division of Gastroenterology, Departments of Medicine and Genetics, and Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104

7. National Cancer Institute, Center for Cancer Research, Bethesda, Maryland 20892

8. GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426

Funder

National Institute of health

Harriet Ellison Woodward Trust endowment

NIH

Publisher

Oxford University Press (OUP)

Subject

Toxicology

Reference70 articles.

1. Resveratrol affects CYP1A expression in rainbow trout hepatocytes;Aluru;Aquat. Toxicol.,2006

2. Mechanisms of alcoholic pancreatitis;Apte;J. Gastroenterol. Hepatol.,2010

3. Bimodal targeting of cytochrome P450s to endoplasmic reticulum and mitochondria: The concept of chimeric signals;Avadhani;FEBS J.,2011

4. Cancer chemoprevention by resveratrol: In vitro and in vivo studies and the underlying mechanisms (review);Aziz;Int. J. Oncol,2003

5. Mitochondrial targeting of cytochrome P450 (CYP) 1B1 and its role in polycyclic aromatic hydrocarbon-induced mitochondrial dysfunction;Bansal;J. Biol. Chem.,2014

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