Characterization of Triptolide-Induced Hepatotoxicity by Imaging and Transcriptomics in a Novel Zebrafish Model

Author:

Vliegenthart Adriaan D. Bastiaan1,Wei Chunmin12,Buckley Charlotte1,Berends Cécile1,de Potter Carmelita M. J.1,Schneemann Sarah1,Del Pozo Jorge3,Tucker Carl4,Mullins John J.1,Webb David J.1,Dear James W.1

Affiliation:

1. Edinburgh University/BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, Edinburgh EH16 4TJ, UK

2. Center for Drug Evaluation, China Food and Drug Agency, Beijing 100083, China

3. Easter Bush Pathology, Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Easter Bush Campus, Roslin, Midlothian EH25 9RG, UK;

4. Biomedical Research Resources, The College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh EH16 4TJ, UK

Publisher

Oxford University Press (OUP)

Subject

Toxicology

Reference53 articles.

1. Deleterious effects of reactive metabolites;Attia;Oxidat. Med. Cell. Longevity,2010

2. Complementary and alternative medicine use among adults: United States, 2002;Barnes;Adv. Data,2004

3. Herbal medicine in the United States: Review of efficacy, safety, and regulation: Grand rounds at University of California, San Francisco Medical Center;Bent;J. Gen. Intern. Med.,2008

4. Review article: Herbal and dietary supplement hepatotoxicity;Bunchorntavakul;Aliment. Pharmacol. Ther.,2013

5. Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F;Chen;Leuk. Lymphoma,2001

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