Role of Cytochromes P450 1A1/2 in Detoxication and Activation of Carcinogenic Aristolochic Acid I: Studies with the Hepatic NADPH:Cytochrome P450 Reductase Null (HRN) Mouse Model

Author:

Levová Kateřina,Moserová Michaela,Kotrbová Věra,Šulc Miroslav,Henderson Colin J.,Wolf C. Roland,Phillips David H.,Frei Eva,Schmeiser Heinz H.,Mareš Jaroslav,Arlt Volker M.,Stiborová Marie

Publisher

Oxford University Press (OUP)

Subject

Toxicology

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3. Environmental pollutant and potent mutagen 3-nitrobenzanthrone forms DNA adducts after reduction by NAD(P)H:quinone oxidoreductase and conjugation by acetyltransferases and sulfotransferases in human hepatic cytosols;Cancer Res.,2005

4. Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice;Carcinogenesis,2008

5. Human enzymes involved in the metabolic activation of the environmental contaminant 3-nitrobenzanthrone: evidence for reductive activation by human NADPH:cytochrome p450 reductase;Cancer Res.,2003

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