Brain Vacuolation Resulting From Administration of the Type II Ampakine CX717 Is An Artifact Related to Molecular Structure and Chemical Reaction With Tissue Fixative Agents-Reference-Cited by-同舟云学术

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Brain Vacuolation Resulting From Administration of the Type II Ampakine CX717 Is An Artifact Related to Molecular Structure and Chemical Reaction With Tissue Fixative Agents

Published:2017-12-15 Issue:2 Volume:162 Page:383-395
ISSN:1096-6080
Container-title:Toxicological Sciences
language:en
Short-container-title:

Author:

Purcell Richard¹,Lynch Gary²,Gall Christine²,Johnson Steven³,Sheng Zhong⁴,Stephen Michael Rajesh⁵^ORCID,Cook James⁵,Garman Robert H⁶,Jortner Bernard⁷,Bolon Brad⁸,Radin Daniel¹,Lippa Arnold¹

Affiliation:

1. SVP R&D, RespireRx Pharmaceuticals, Inc, Glen Rock, New Jersey 07452

2. University of California Irvine, Irvine, California

3. SAJ Pharmaconsulting, LLC

4. PsychoGenics Inc, Tarrytown, New York

5. University of Wisconsin- Milwaukee, Wisconsin

6. Consultants in Veterinary Pathology, Murrysville, Pennsylvania

7. Virginia Tech, Blacksburg, Virgina

8. GEMpath Inc, Longmont, Colorado, 80504

Publisher

Oxford University Press (OUP)

Subject

Toxicology

Link

http://academic.oup.com/toxsci/article-pdf/162/2/383/24474102/kfx277.pdf

Reference34 articles.

1. Enthalpies of combustion of 2, 4, 6-trimethylbenzonitrile, 2, 4, 6-trimethylbenzonitrile N-oxide, 2, 6-dimethylbenzonitrile, 2, 4, 6-trimethoxybenzonitrile, and 2, 4, 6-trimethoxybenzonitrile N-oxide: the dissociation enthalpies of the (N_O) bonds;Acree;Thermodynamics,1991

2. Pharmacology of ampakine modulators: From AMPA receptors to synapses and behavior;Arai;Curr. Drug Targets,2007

3. Benzamide-type AMPA receptor modulators form two subfamilies with distinct modes of action;Arai;J. Pharmacol. Exp. Ther,2002

4. STP position paper: Recommended practices for sampling and processing the nervous system (brain, spinal cord, nerve, and eye) during nonclinical general toxicity studies;Bolon;Toxicol. Pathol.,2013

5. The role of astroglia in neuroprotection;Bélanger;Dialog. Clin. Neurosci,2009

Cited by 12 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. High-Impact AMPAkines Elevate Calcium Levels in Cortical Astrocytes by Mobilizing Endoplasmic Reticular Calcium Stores;Neuroglia;2024-09-09

2. Preclinical Pharmacology of the Low-Impact Ampakine CX717;Future Pharmacology;2024-08-16

3. AMPA receptors play an important role in the biological consequences of spinal cord injury: Implications for AMPA receptor modulators for therapeutic benefit;Biochemical Pharmacology;2024-05

4. Pattern sensitivity of ampakine-hypoxia interactions for evoking phrenic motor facilitation in anesthetized rat;Journal of Neurophysiology;2024-02-01

5. High impact AMPAkines induce a Gq-protein coupled endoplasmic calcium release in cortical neurons: a possible mechanism for explaining the toxicity of high impact AMPAkines;2024-01-29

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